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5-HT receptor agonists A diverse range of compoundsproducing a variety of actions have been found to activateone or more subtypes of 5-HT receptors.

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A recent meta-analysisin the New England Journal of Medicine (Turner et al., 2008)suggested widespread exaggeration of effect sizes in rela-tion to many blockbuster (billion-dollar) antidepressantcompounds.